Pl provide more details of scenario - which object etc
Also ref - CRM Middleware Survival Guide - CRM - SCN Wiki
Corresponding queues in status SYFAIL
Double-click on the SYSFAIL and see what error is given. Perform note/message search on the error
If the outbound queue in the CRM is stuck in SYSFAIL, there will usually be a corresponding short dump in the R3. Reprocessing the queue will reproduce the dump.
Failed outbound queues on the R3 will also usually have a corresponding short dump on the R3.
If the inbound queue on the CRM has status SYSFAIL, check for corresponding BDoc’s in transaction SMW01. Please refer to the section “BDoc’s in Error/Intermediate Status”. Also, check for corresponding short dumps on the CRM.