That make sense, from your last answer (sample of code) I thought you want to disable. Enable fields is another different story, If is disabled by the standard (customizing or a standard implementation of a BADI) you can change the UI and make it enabled but probably when you'll try to save, the value won't reach the database. You will need to debug the GET_I and see why the system is disabling the filed...it's time to dig 
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Re: Opportunity Product Line Item Numbers
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